Antihistamine Substances

Histamine and antihistamine substances.

Synthesis and Characterization of Related Substances of Rupatadine Fumarate: an Antihistamine Drug

Rupatadine fumarate is a potent dual antagonist of histamine and platelet-activating factor antagonist (PAF antagonist) and used to treat allergies. During the process development of rupatadine fumarate, five related substances were observed in Rupatadine fumarate and one new related compound was observed during the stress oxidative degradation study. These related substances were identified as...

Antihistamine Toxicosis

Antihistamines are H1-receptor antagonists widely used in human and veterinary medicine to provide symptomatic relief of allergic signs caused by histamine release, including pruritus and anaphylactic reactions. Antihistamines are also commonly used as sedatives and antiemetics. 1 Antihistamines can be divided into first and second-generation (also called nonsedating) agents (Table 1). First-ge...

Antihistamine use in children.

This review provides an overview of the use of antihistamines in children. We discuss types of histamine receptors and their mechanism of action, absorption, onset and duration of action of first-generation and second-generation H(1)-antihistamines, as well as elimination of H(1)-antihistamines which has important implications for dosing in children. The rationale for the use of H(1)-antihistam...

Differentiating Antihistamine Efficacy from Potency*

The ideal antihistamine would optimize both receptor and clinical pharmacology, combining high receptor affinity, reflected by high potency, with outstanding clinical efficacy. Because the basic concepts of potency and efficacy are often confused and used interchangeably within the scientific and pharmaceutical industry, the distinction between these 2 terms must be understood in order for them...